ACTA VETERINARIA ET ZOOTECHNICA SINICA ›› 2017, Vol. 48 ›› Issue (2): 201-206.doi: 10.11843/j.issn.0366-6964.2017.02.002

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Research Advances in Excretory-secretory Products of Fasciola spp.

TIAN Ai-ling,ZHU Xing-quan,HUANG Si-yang*   

  1. (State Key Laboratory of Veterinary Etiological Biology/Key Laboratory of Veterinary Parasitology of Gansu Province, Lanzhou Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Lanzhou 730046, China)
  • Received:2016-08-15 Online:2017-02-23 Published:2017-02-23

Abstract:

Fascioliasis is a sort of zoonotic disease caused by Fasciola spp., which can cause a large number of deaths in animals. It is considered to be a major problem for effecting on global public health and husbandry economic development. The method of resistance of host immune response that can survive in the host during the process of long-term mutual struggle between Fasciola spp. and its host. However, the excretory-secretory products (ESP) in different developmental stages of Fasciola spp. play a significant role in this process. In fact, ESP can be divided into oxidative stress related proteins, proteins related to energy metabolism and the proteasome associated proteins according to the functions. The ESP play important roles in the immune evasion of the Fasciola spp. Therefore, this dissertation expounded its functions with the purpose of providing implications for the research of new vaccines or drugs.

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